Researchers have found the cause of a serious virus attack on the lungs. They have described how various types of immune cells (immune cells) develop in the lungs and which of these can cause lung disease. This discovery may open the way for the development of new treatments to combat many diseases, including the coronavirus (Covid-19).
There was limited study yet on the growth of these cells called macrophages. This new study by researchers from the Karolinska Institute of Sweden has been published in the journal Immunity.
He used a model to study the development of lame macrophages. In addition to looking at gene activity and RNA sequencing in cells, it explored how blood monocytes are transformed into lung macrophages.
Team Willinger, assistant professor at the Carolinska Institute, who led the study, said, ‘Our research shows that classical monocytes enter the airways and lung tissue. It then transforms into macrophages. This provides protection to lung health and functioning. According to Willinger, we have also identified a particular type of monocyte called HLA-DRHI. It is an intermediate immune cell between the blood monocyte and the airway macrophage. Macrophages are immune cells that protect the lungs from viral attacks. However, under certain conditions, some of these cells can cause chronic obstructive pulmonary diseases (COPD) such as lung disease and COVID-19.