As the Donald Trump administration froze billions of dollars in future federal grants to Harvard University, the Ivy League institution hunkered down, saying it would continue to oppose “illegal government overreach” aimed at stifling research.

The latest move specifically targets research grant funding and is estimated to impact over $1 billion a year, CNN reported.

In a sharp clap back at Trump’s latest action, Harvard blasted the administration for withholding funding for “life-saving research and innovation”, adding that stopping federal grants would impose “unprecedented and improper control”.

Harvard, the wealthiest university in the US, said it would have “chilling implications” for higher education.

“Today’s letter makes new threats to illegally withhold funding for lifesaving research and innovation in retaliation against Harvard for filing its lawsuit on April 21,” the university said.

Last month, Harvard, one of the top-ranked universities in the world, filed a lawsuit after the Trump administration froze more than $2.2 billion in grants.

The latest development intensifies the clash between Trump and Harvard over academic freedom, and combating campus antisemitism.

“Harvard will continue to comply with the law, promote and encourage respect for viewpoint diversity, and combat antisemitism in our community,” it said.

“Harvard will also continue to defend against illegal government overreach aimed at stifling research and innovation that make Americans safer and more secure,” the statement further said.

TRUMP SEEKS COMPLIANCE WITH DEMANDS

On Monday, a letter sent to Harvard president Alan Garber by the Education Secretary accused the university of consistent “violations of its legal duties” and stated that it would no longer be eligible for future research grants.

The letter sought compliance with the White House’s set of demands, which include changes to its hiring, admissions and teaching practices to curb antisemitism. A ban on face masks on campus and the closing of Harvard’s diversity, equity and inclusion programs are some of the other demands.

Trump has also warned Harvard of revoking its tax-exempt status apart from enforcing a ban on enroling foreign students. International students comprised more than 27% of Harvard’s enrolment this year.